Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.570 | AlteredExpression | disease | BEFREE | Although there are disparities in pathophysiology and epidemiology between male and female patients with HF, it remains unclear whether there is gender difference in myostatin expression and whether it is associated with weight loss in HF patients. | 28465115 | 2017 | ||||
|
0.570 | AlteredExpression | disease | BEFREE | Serum myostatin levels were higher in CHF patients than in controls. | 31056368 | 2019 | ||||
|
0.570 | AlteredExpression | disease | BEFREE | In late-stage CHF, exercise training led to a 36% reduction of the mRNA and a 23% decrease of the myostatin protein compared to baseline. | 21450574 | 2012 | ||||
|
0.570 | AlteredExpression | disease | BEFREE | Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. | 29069231 | 2017 | ||||
|
0.570 | Biomarker | disease | CTD_human | However, the expression of myostatin in chronic heart failure resulting from volume-overload and after treatment with beta-blockers is little known. | 16968467 | 2006 | ||||
|
0.570 | Biomarker | disease | BEFREE | To therapeutically influence skeletal muscle wasting, direct inhibition of myostatin was shown to positively impact skeletal muscle mass in heart failure, suggesting a promising strategy for the treatment of cardiac cachexia in the future. | 21421824 | 2011 | ||||
|
0.570 | Biomarker | disease | RGD | However, the expression of myostatin in chronic heart failure resulting from volume-overload and after treatment with beta-blockers is little known. | 16968467 | 2006 | ||||
|
0.570 | Biomarker | disease | BEFREE | We describe the development of the first ELISA for myostatin immunoreactivity and its validation during recompensating therapy for CHF. | 22561185 | 2012 | ||||
|
0.570 | Biomarker | disease | BEFREE | Circulating and local myostatin is elevated in chronic heart failure and poses a major player in cardiac cachexia. | 24680839 | 2014 |